Toxicities associated with checkpoint inhibitors—an overview
Identifieur interne : 000315 ( Main/Exploration ); précédent : 000314; suivant : 000316Toxicities associated with checkpoint inhibitors—an overview
Auteurs : Laura Spiers ; Nicholas Coupe ; Miranda PayneSource :
- Rheumatology (Oxford, England) [ 1462-0324 ] ; 2019.
Abstract
Immunotherapy has an increasing role in the management of cancer, both in metastatic disease and as an adjuvant therapy. However, sensitization of the immune system with checkpoint inhibitors comes with a unique side effect profile. Full appreciation of this can take some time to emerge as some adverse events are rare, or can be subtle and potentially overlooked. Clinician awareness of these side effects can be particularly important in patients with pre-existing autoimmune conditions. Here we describe common symptoms and diagnostic strategies for organ-specific side effects of anti-CTLA-4 and anti-PD-1/PD-L1 immunotherapy agents.
Url:
DOI: 10.1093/rheumatology/kez418
PubMed: 31816085
PubMed Central: 6900917
Affiliations:
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Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donia, M" uniqKey="Donia M">M Donia</name></author><author><name sortKey="Pedersen, M" uniqKey="Pedersen M">M Pedersen</name></author><author><name sortKey="Svane, Im" uniqKey="Svane I">IM. Svane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gettings, Ej" uniqKey="Gettings E">EJ Gettings</name></author><author><name sortKey="Hackett, Ct" uniqKey="Hackett C">CT Hackett</name></author><author><name sortKey="Scott, Tf" uniqKey="Scott T">TF. Scott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, B" uniqKey="Lee B">B Lee</name></author><author><name sortKey="Wong, A" uniqKey="Wong A">A Wong</name></author><author><name sortKey="Kee, D" uniqKey="Kee D">D Kee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Db" uniqKey="Johnson D">DB Johnson</name></author><author><name sortKey="Sullivan, Rj" uniqKey="Sullivan R">RJ Sullivan</name></author><author><name sortKey="Ott, Pa" uniqKey="Ott P">PA Ott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gutzmer, R" uniqKey="Gutzmer R">R Gutzmer</name></author><author><name sortKey="Koop, A" uniqKey="Koop A">A Koop</name></author><author><name sortKey="Meier, F" uniqKey="Meier F">F Meier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menzies, Am" uniqKey="Menzies A">AM Menzies</name></author><author><name sortKey="Johnson, Db" uniqKey="Johnson D">DB Johnson</name></author><author><name sortKey="Ramanujam, S" uniqKey="Ramanujam S">S Ramanujam</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Coupe, Nicholas" sort="Coupe, Nicholas" uniqKey="Coupe N" first="Nicholas" last="Coupe">Nicholas Coupe</name><name sortKey="Payne, Miranda" sort="Payne, Miranda" uniqKey="Payne M" first="Miranda" last="Payne">Miranda Payne</name><name sortKey="Spiers, Laura" sort="Spiers, Laura" uniqKey="Spiers L" first="Laura" last="Spiers">Laura Spiers</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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